I have the same issue under Windows XP SP3 and I find out that I can't invoke pspice from the start menu. You rename %HOME%/CDSSETUP to what ? I found the variable in the windows system variables but also in some Orcad ini files too. Orcad was installed in a virtual partition D:\ and the %HOME%/CDSSETUP points to the right place that is D:\Windows Section\OrCAD_16.6_Lite which is the installation folder I choose when installing Orcad so everything seems to be correct for me and there is only one user account on my computer.
I have uninstalled it and reinstalled it in the default directory C:\OrCAD\OrCAD_16.6_Lite\ and it is the same problem
OrCAD Capture CIS Lite -> no problem
Magnetic Parts Editor -> no problem
Model Editor -> error message: This application has quit unexpectedly. To help Cadence detect and analyse the problem archive the current project...
Simulation Manager -> no problem
Stimulus Editor -> error message: This application has quit unexpectedly. To help Cadence detect and analyse the problem archive the current project...
PSpice Advanced Analysis Lite -> no problem
PSpice AD Lite -> nothing happen !
Any ideas !
Thank you, bye.